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What is Xanax?

Xanax (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH. Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety.

Xanax is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Xanax may also be used for purposes not listed in this medication guide.

Xanax Warnings

Do not take Xanax if you are allergic to alprazolam, any of the inactive ingredients of the medication, or other benzodiazepines, like Librium, Tranxene, Valium, Ativan, or Serax and others.

Do not take Xanax if you have narrow-angle glaucoma.

Do not take Xanax if you are taking the antifungal medications Sporanox or Nizoral.

Xanax can make you drowsy and decrease your ability to drive safely or operate machinery. You may become particularly sleepy if Xanax is taken with other drugs that cause drowsiness, or if you are elderly or debilitated.

Xanax may be habit-forming, so do not take higher doses of the medication or use it for a longer time than your doctor recommends. You can become tolerant, making the drug less effective.

Before taking Xanax, tell your doctor if you have:

  • Depression
  • Suicidal thoughts
  • Breathing problems
  • History of alcoholism or drug abuse
  • Personality disorder
  • Liver or kidney problems
  • Tell your doctor what other prescription and nonprescription medications, vitamins, and nutritional supplements that you take, because these may interact with Xanax. Also, tell your doctor if you smoke.

Talk to your doctor if you have symptoms of your condition between doses. Do not increase the dose without talking to your doctor first, even if you think the medication doesn't work anymore.

Dosage

Because the management of panic disorder often requires the use of average daily doses of alprazolam tablets above 4 mg, the risk of dependence among panic disorder patients may be higher than that among those treated for less severe anxiety. Experience in randomized placebo-controlled discontinuation studies of patients with panic disorder showed a high rate of rebound and withdrawal symptoms in patients treated with alprazolam tablets compared to placebo treated patients.

Relapse or return of illness was defined as a return of symptoms characteristic of panic disorder (primarily panic attacks) to levels approximately equal to those seen at baseline before active treatment was initiated. Rebound refers to a return of symptoms of panic disorder to a level substantially greater in frequency, or more severe in intensity than seen at baseline. Withdrawal symptoms were identified as those which were generally not characteristic of panic disorder and which occurred for the first time more frequently during discontinuation than at baseline.

In a controlled clinical trial in which 63 patients were randomized to alprazolam tablets and where withdrawal symptoms were specifically sought, the following were identified as symptoms of withdrawal: heightened sensory perception, impaired concentration, dysosmia, clouded sensorium, paresthesias, muscle cramps, muscle twitch, diarrhea, blurred vision, appetite decrease and weight loss. Other symptoms, such as anxiety and insomnia, were frequently seen during discontinuation, but it could not be determined if they were due to return of illness, rebound or withdrawal.